BONIVA is a prescription medicine for the management of postmenopausal osteoporosis. You should not take BONIVA if you have low blood calcium, cannot sit or stand for at least 60 minutes, have severe kidney disease, or are allergic to BONIVA. Stop taking BONIVA and tell your healthcare provider if you experience difficult or painful swallowing, chest pain, or severe or continuing heartburn, as these may be signs of serious upper digestive problems. Follow the dosing instructions for the once-monthly BONIVA 150 mg Tablet carefully to lower the chance of these events occurring. Side effects are generally mild or moderate and may include diarrhea, pain in the arms or legs, or upset stomach. If you develop severe bone, joint, and/or muscle pain, contact your healthcare provider. Your healthcare provider may also recommend a calcium and vitamin D supplement.

BONIVA Injection is indicated for the treatment of osteoporosis in postmenopausal women. BONIVA Injection must be administered intravenously (IV) only by a healthcare professional. Do NOT administer BONIVA Injection to yourself. Patients with severe kidney problems or who are allergic to BONIVA should not receive BONIVA Injection. You should have a blood test to check your kidneys prior to each injection of BONIVA. Your doctor must correct low blood calcium and vitamin D levels before starting BONIVA Injection therapy. You must also take calcium and vitamin D supplements while receiving BONIVA Injection therapy.

Side effects are usually mild and of brief duration. The most common side effects with BONIVA Injection are bone, muscle, or joint pains, flu-like illness and headache. Flu-like symptoms usually occur only after the first injection of BONIVA. If you develop severe bone, joint, and/or muscle pain, contact your healthcare provider.